Christina Applegate Facing the ‘Fight of Her Life’ Amid MS Battle: She’s in ‘Physical Agony’ Every Day

Christina Applegate
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Who is this?
Christina Applegate (born November 25, 1971) is a retired American actress. She gained recognition in the late 1980s for playing Kelly Bundy in the Fox sitcom Married... with Children (1987–1997). Her titular role in the sitcom Jesse (1998–2000), earned her first nomination for the Golden Globe Award for Best Actress – Television Series Musical or Comedy. For her guest role in the NBC sitcom Friends (2002–2003), she won the Primetime Emmy Award for Outstanding Guest Actress in a Comedy Series. She received additional Emmy and Golden Globe nominations for her roles in the television sitcom Samantha Who? (2007–2009), starred in a short-lived sitcom Up All Night (2011–2012), and the dark tragicomedy series Dead to Me (2019–2022). Applegate served as a producer of all three aforementioned projects. Applegate has achieved success in films of varying genres, particularly in comedies such as Don't Tell Mom the Babysitter's Dead (1991), The Big Hit (1998), The Sweetest Thing (2002), Anchorman: The Legend of Ron Burgundy (2004) and Anchorman 2: The Legend Continues (2013), Hall Pass (2011), Vacation (2015), Bad Moms (2016), and Crash Pad (2017). On stage, Applegate received a nomination for the Tony Award for Best Actress in a Musical for her debut performance as the title character in the Broadway musical revival Sweet Charity (2005). After being diagnosed with multiple sclerosis in August 2021, Applegate announced she would step away from appearing on-screen, but would continue doing voice work. She published a memoir in 2026, an instant New York Times Best Seller, where she focused on resilience and self-acceptance.
Career
- 1971Born
- 2003Won Primetime Emmy Award
- 2003Won Primetime Emmy Award for Outstanding Guest Actress in a Comedy Series
- 2005Won Theatre World Award
- 2009Won 35th People's Choice Awards
- 2009Won TV Land Award
Trivia
- •Place of birth: Hollywood
- •Citizenship: United States
- •Known as: stage actor, musical theatre actor, film actor, television actor
- •Spouse: Martyn LeNoble
What happened recently
Christina Applegate 'Hospitalized Since Late March' amid MS Battle — Weeks After Revealing Illness Confined her to Bed
Joanna Cassidy Didn’t Know About Turmoil in Christina Applegate’s Life While Filming Don’t Tell Mom the Babysitter’s Dead (Exclusive)
There is a passage in Christina Applegate's 'You With The Sad Eyes' that will stay with me forever
Christina Applegate still has her ‘dry’ sense of humor amid MS battle, says pal
Christina Applegate’s former co-star gives rare update on actress’s ‘very hard’ MS battle after hospitalization
David Faustino Praises Christina Applegate’s Strength Amid Health Battle: ‘She Keeps Her Humor’ (Exclusive)
David Faustino says Christina Applegate still has her 'dry, sarcastic sense of humor' as she battles MS
Christina Applegate Explains Why She Worried She’d Be a ‘Sell Out’ by Making “Don’t Tell Mom the Babysitter’s Dead”
Jamie-Lynn Sigler Shares Update on Christina Applegate Amid Health Concerns - E! News
Christina Applegate’s Battle With MS Has Been ‘Treacherous,’ But Actress Is ‘a Fighter’
Christina Applegate Breaks Silence Amid Hospitalization Reports to Give Health Update
Christina Applegate Speaks Out After Hospitalization: I’m Getting ‘Better Every Day’ and ‘Health Issues Are a Constant For Me, but I’m a Strong Chick’
Everything Christina Applegate Has Said About Her Multiple Sclerosis Battle: Diagnosis and More
Christina Applegate on learning to live with joy and pain : Wild Card with Rachel Martin
Who Is Christina Applegate's Husband? What to Know About Dutch Musician Martyn LeNoble
Christina Applegate says teen daughter is 'my dedication to life' amid MS struggles
Christina Applegate on life with multiple sclerosis: ‘I won’t lie and say any of this is a blessing’
Christina Applegate Shares the 'Raw, Honest' Truth About Her Life in New Memoir (Exclusive)
Christina Applegate, Jamie-Lynn Sigler open up about bond they've formed through MS battles - ABC News - Breaking News, Latest News and Videos
Christina Applegate Invites Others with MS to Share “the Good, the Bad, the Ugly…the Diapers” Through New Online Platform